Renal dysplasia in dogs is a severe kidney disease that causes great suffering for the affected individual. The disease disturbs the development of the kidneys which leads to an immature microscopic structure of the kidney and smaller kidneys than normal. A dog with renal dysplasia only lives between 4 and 24 months, because of kidney failure. There are different ways to establish a diagnosis, but the most common way today is to take a renal biopsy. In a scientific study, ultrasound based diagnosis was shown to match the histopathological picture of the disease.

Bull terrier hereditary nephritis is caused by a mutation that leads to an inadequate synthesis of collagen type IV, which is an important component in the basement membranes. The inheritance of the mutation is autosomal dominant in bull terriers and progression to renal failure takes variable time, from several months to ten years. Proteinuria is the first clinical sign of the disease and the diagnosis is confirmed by transmission electron microscopy of renal tissue where typical ultrastructural changes in the glomerular basement membrane (GBM), thickening and multilaminar splitting are found. This study was performed in order to find out the occurrence of hereditary nephritis in bull terriers in Sweden through examination of urine samples and renal tissue and comparisons with how the disease is described in the literature. Urine samples from 76 Swedish bull terriers were collected and examined for proteinuria.

Renal dysplasia is a developmental anomaly of the kidneys which is considered to be the primary lesion in juvenile progressive nephropathy, a condition leading to chronic renal failure in young dogs. It is defined as disorganised development of the renal parenchyma due to abnormal differentiation, and pathological lesions include persistent foetal structures, dysplastic tubules and cartilaginous and osseus metaplasia. The aetiology of renal dysplasia in dogs is still unknown, but possible causes are infection with canine herpesvirus, teratogenic substances or intrauterine ureteral obstruction. In some breeds renal dysplasia is a familial or inherited disease. Clinical signs of chronic renal failure, such as polyuria, polydipsia, vomiting, weight loss, anorexia, lethargy and anemia, usually appear before the age of 2 years.

This study examines if the prediction of cardiovascular disease in hypertensive patients can be improved upon when renal function and microalbuminuria are added to the classical risk factors The predictive capability of a model is measured by discrimination, calibration, reclassification and Harrell's C.The results are ambigious. In most cases, microalbuminuria should be included in the model, but the results regarding the other measures of renal function are varied. Therefore, the selection of risk factors to include in the model depends on which measure of prediction one prioritizes..

The occurrence of small amounts of albumin in urine, microalbuminuria (MA), is used both in human- and veterinary medicine as an indicator for patients who have developing proteinuria. Proteinuria can be prerenal, renal or postrenal which is important to establish during an investigation. With conventional methods decreased renal function is not detected until 70 % of renal function is lost. The ability to detect and start a treatment earlier might reverse or slow the progression of disease. The purpose of this study was to investigate the reliability of Heska® E.R.D.-Health Screen?, a test for microalbuminuria in dogs, to detect albuminuria.

Renal dysplasi (RD) is a congenital chronic Renal disease affecting young dogs. It is a rather common disease that occurs in a large number of dogs and in some breeds there is a familiar incidence or suspected hereditary background. Both the etiology and pathogenesis are still unknown, but a theory about the cause of RD is that the two components that form the kidney, the uretheric bud and the metanephrogenic blastema, don´t interact normally in the embryo. Kidneys affected by RD contain fetal (immature) structures that are inappropriate for the state of development/age of the dog and abnormal structures caused by an abnormal differentiation. Affected dogs usually are under .

Both serum creatinine and measuring GFR can be used to evaluate renal function in dogs suspected to have chronic kidney disease (CKD). Although high creatinine levels usually indicate Renal disease, normal creatinine levels can be present in dogs with decreased renal filtration. Measuring GFR is generally believed to be the most accurate way of detecting decreased renal filtration and scintigraphy GFR using 99mTc-DTPA has been found to correlate well with the ?gold standard? inulin clearance method.When measuring GFR by scintigraphy, 99mTc-DTPA is injected intravenously and radioactive decay of technetium gives rise to gamma radiation, which is registered by a gamma camera. Pictures and curves of radioactivity in the kidneys are generated by means of a computer program.

Background: Diabetes mellitus is a chronic disease that manifests as an increased level of glucose in the blood. According to the World Health Organization (WHO), 347 million people have diabetes worldwide. In year 2004, 3.4 million people died from the consequences of high blood glucose. In the Swedish population the prevalence of diabetes is estimated to 3-4 %, out of which 85-90% are Type 2. Among senior citizens a prevalence of diabetes is seen in Sweden up to 14 - 15%.

Parkinson's disease is a progressive degenerative neurological disorder. In Sweden there are 15 000-20 000 individuals affected by the disease.The aim of this study was to investigate the prevalence of oral diseases in individuals with Parkinson's disease. The material for the literature review was gathered in the medical database PubMed. Keywords used for the data research were ?Parkinson?s disease?, ?oral diseases?, ?dry mouth?, ?gingivitis?, ?caries? and ?periodontitis?.

Background:Alzheimer's disease is a disease that primarily affects the elderly but also younger people. Alzheimer's disease is a type of dementia which means that you get changes in the cerebral cortex and cells gradually die. The disease causes memory loss and things that were obvious before will be difficult for the sufferer. Alzheimer's disease also affects next of kin to a large degree; they will have to take a great responsibility. The next of kin are entitled to support from healthcare.Aim:The aim was to highlight next of kin' experiences of healthcare to their family members with Alzheimer's disease.Method: The study was based on narratives, which in this case means analysis of autobiographies.

The aim of the study was to describe how women and men with diagnosed heart disease experience their health-related quality of life and what differences there is between genders in their quality of life and also describe problems after receiving the diagnosis. The study also aimed to describe rehabilitation of patients with heart disease. The study was a descriptive literature study based on scientific articles. It emerged that both women and men with heart disease experienced lower quality of life compared to normative data. There was a significant difference between women and men both one year and three years after receiving the diagnosis heart disease, which showed that women experienced lower quality of life than men.

Background: Inflammatory bowel disease (IBD) is an umbrella term for ulcerative colitis and Crohn's disease. These are characterized by a chronic inflammation of the intestinal mucosa. Living with chronic illness meant that life changed significantly. Quality of life was affected for these individuals and was stressful in their lives. Aim: The aim was to describe the experiences of living with inflammatory bowel disease. Method: A qualitative literature review was chosen to analyze articles that were related to the aim of this study. Results: Based on the chosen articles five themes were created; Commuting between hope and fear, symptoms of the disease and medication become everyday focus, struggling with  the new identity, desire to control the disease- do I control my illness or does it control me and social relationships are affected. Conclusion: Inflammatory bowel disease is a distressing disease and can cause limitations in social life due to lack of knowledge by others about the disease. The affected felt a loss of control in their life due to the difficulty in managing the symptoms.

Background:Alzheimer's disease is a disease that primarily affects the elderly but also younger people. Alzheimer's disease is a type of dementia which means that you get changes in the cerebral cortex and cells gradually die. The disease causes memory loss and things that were obvious before will be difficult for the sufferer. Alzheimer's disease also affects next of kin to a large degree; they will have to take a great responsibility. The next of kin are entitled to support from healthcare.Aim:The aim was to highlight next of kin' experiences of healthcare to their family members with Alzheimer's disease.Method: The study was based on narratives, which in this case means analysis of autobiographies.

Diseases associated with monocytosis in Swedish dogs - a retrospective study. The purpuse of this retrospective study is to determine which diseases are associated with pronounced monocytosis in Swedish dogs. Records of 153 dogs with monocytosis were evaluated. The most common cause was infectious diseases (49%) of which pyometra was seen in 23% of the cases, cystitis and fever of unknown origin each in 13% and gastroenteritis in 12%. Cortison treatment was the second most common cause with 29%. A sixth of the dogs had non inflammatory diseases such as neoplasia, renal- and heartfailure.

Background:Alzheimer's disease is a disease that primarily affects the elderly but also younger people. Alzheimer's disease is a type of dementia which means that you get changes in the cerebral cortex and cells gradually die. The disease causes memory loss and things that were obvious before will be difficult for the sufferer. Alzheimer's disease also affects next of kin to a large degree; they will have to take a great responsibility. The next of kin are entitled to support from healthcare.Aim:The aim was to highlight next of kin' experiences of healthcare to their family members with Alzheimer's disease.Method: The study was based on narratives, which in this case means analysis of autobiographies.